IDEXX SDMA testing

Why it's essential to run SDMA every time you run creatinine and BUN

SDMA provides deeper insights because of its 3 key attributes

  • SDMA is a biomarker for kidney function.
  • SDMA increases early, with only 25% of kidney function lost.1–3
  • SDMA is specific for kidney function and less impacted by extrarenal factors, including body condition, advanced age, and disease state.4,5

Read: How SDMA detects chronic kidney disease earlier

Common cases when SDMA is essential

When SDMA is increased and other results are normal
SDMA detected Bess' chronic kidney disease (CKD), allowing treatment to begin earlier.

Bess showed some moderate periodontal disease, and other examination parameters were within normal limits. Learn why it's important to pay attention when SDMA is increased and other factors look normal. 
Read the case study.


When diagnosing hyperthyroid patients
SDMA helped detect CKD in Zeke, a hyperthyroid cat.

SDMA diagnoses CKD more in hyperthyroid cats than creatinine and BUN alone because SDMA is not impacted by changes in muscle mass.4,5 Read the case study or learn more about hyperthyroid cats and the IDEXX SDMA Test.


When assessing kidney function in puppies and kittens

In puppies, the IDEXX SDMA Test reference interval has been determined to be slightly higher (0–16 μg/dL) than the adult reference interval (0–14 μg/dL). A pediatric reference interval study confirmed that the adult cat reference interval of 0–14 µg/dL is appropriate for use in kittens. 

Assess kidney function of puppies and kittens using SDMA

Deeper insights

Learn more about why SDMA is an essential part of every chemistry panel 

Swipe to see our signature software and devices.

Two options: same reliable results

The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analyzers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories

Note: SDMA is symmetric dimethylarginine.

References

  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/guidelines. Accessed May 9, 2018.
  7. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  8. Lulich JP, Osborne CA, O'Brien TD, Polzin DJ. Feline renal failure: questions, answers, questions. Compend Contin Educ Pract Vet. 1992;14(2):127–153.
  9. Brown SA. Renal dysfunction in small animals. The Merck Veterinary Manual website. www.merckvetmanual.com/urinary_system/noninfectious_diseases_of_the_urinary_system_in_small_animals/renal_dysfunction_in_small_animals. Updated October 2013. Accessed May 9, 2018.